Inga F. Dolmanova, Associate Professor,
Ph.D. - head of the laboratory
From left to right (standing): I.A.Veselova,
Inga F. Dolmanova, Ph.D., Associate Professor Tatyana N. Shekhovtsova, Dr.Sci., Professor Mikhail K. Beklemishev, Ph.D., Senior Research Scientist Svetlana V. Muginova, Ph.D., Junior Research Scientist Ludmila E. Grishina, Ph.D., Assistant Professor Irina A. Veselova, Junior Research Scientist
Laboratory research is devoted to kinetic methods of analysis in their catalytic variant. We develop methods for determination of inorganic and organic catalysts and enzymes and of those compounds which affect the catalytic activity of catalysts (inhibitors and activators). The most interesting results have been obtained while developing the methods (including express-tests) for the determination of transition metals, such as mercury(II), lead(II), and cadmium(II), N-, S-, and P-containing organic compounds, and phenols in environmental samples, pharmaceutical formulations, and biological liquids.
Effects of different inorganic and organic biologically active compounds on catalytic activity of enzymes of various classes (oxidases, hydrolases) are investigated. Mechanism of effects of enzyme inhibitors and activators is studied. Sensitive, selective, simple and rapid enzymatic methods for determination of enzyme effectors are developed.
A novel approach to analysis is developed which is based on hybrid combination of sorption of the analyte with its subsequent determination directly on the sorbent surface with the use of catalytic methods. The potential analytes include metal ions as well as various organic substances, and the possible area of application of that approach may be rapid out-of-laboratory testing.
Theoretical foundation and practical application of kinetic (catalytic and noncatalytic), biochemical (enzymatic, immunochemical) and biological methods are discussed.