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Ksenia A. Afanasyeva, Anastasia M. Gileva, Elena A. Markvicheva, Ulyana A. Budanova, Yurii L. Sebyakin
Glycolipotripeptide
(N-lactitol-Gly)2-LysC16 and its fluorescently labeled
analogue for visualization of vector systems for biologically active substances
delivery to target cells
Abstract
Abstract. The work is devoted to the preparation of a carbohydrate derivative
of lipotripeptide (N-lactitol-Gly)2-LysC16 of irregular
structure with two terminal residues of D-galactose, a branching link based on
aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a
fluorescent label in a hydrophobic fragment. The developed synthesis scheme
includes universal approaches of peptide chemistry, as well as the stages of
formation of an acyclic carbohydrate based on lactose in the hydrophilic domain
of amphiphile. The compounds are designed to create compositions of vector BAS
delivery systems with the ability to visualize the process of interaction with
target cells.
Key words: transport systems, liver cells, asialoglycoprotein receptors
(ASGPR), glycolipotripeptide, (Gly)2-LysC16, acyclic form of lactose,
derivatives of 1-pyrenbutanol
Copyright (C) Chemistry Dept., Moscow State University, 2002
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