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Anna A. Skuredina, Linara R. Yakupova, Irina M. Le-Deygen, Elena V. Kudryashova
Structural
and functional aspects of the interactions between medical polymers and the
liposoms and bacterial cells
Abstract
Abstract. Polymers
are widely applied as drug delivery systems and implant coatings. The review is
devoted to the mechanisms of interaction of biomedical polymers with model cell
membranes (liposomes) and real biological objects – bacterial cell surfaces. A comparative analysis
of the composition, structure and surface charge of different types of
biological membranes has been outlined. We consider the main methods and
approaches for studying the effect of polymers on the structure and
physico-chemical properties of membranes to uncover adsorption, defects in the
bilayer, violations of the integrity of the bilayer, changes in cell
morphology, etc. The correlation between the observed effects on model and real
objects is analyzed. One of the important tasks of the review is to discover
the key polymer’s characteristic (structure, size, charge, etc.) for the design
of new high-molecular compounds with specified biological properties.
Key words: bacterial
cell surface, liposomes, medical polymers
Copyright (C) Chemistry Dept., Moscow State University, 2002
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