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Maria S. Andrianova, Olga S. Panova, Alexey A. Titov, Natalia
V. Komarova, AlexanderE. Kuznetsov
Electrochemical
biosensors for SARS-CoV-2 detection
Abstract
Abstract. The 2019
coronavirus disease (COVID-19) outbreak has become global. The unprecedented
socioeconomic impact of the pandemic has highlighted the need to improve
existing diagnostic methods and develop new methods to control the spread of
the disease. Traditional technologies such as quantitative real-time polymerase
chain reaction (qRT-PCR) have been considered the gold standard for testing for
COVID-19 since the SARS-CoV-2 genome sequence was published. However, they are
time-consuming, labor-intensive and do not guarantee the absence of false
results. Electrochemical biosensors present alternative approaches to detect
viral nucleic acids or viral antigens. High sensitivity, relatively low cost of
sensors and equipment, convenient management, rapid analysis, and suitability
for miniaturization may contribute to the development of point-of-care (POC)
testing for COVID-19. The review examines and critically discusses modern
electrochemical biosensors for SARS-CoV-2 detection and related technologies.
Key words: coronavirus,
SARS-CoV-2, COVID-19, electrochemical signal, biosensor, nanomaterials,
immunosensor, rapid detection, POC biosensors
Copyright (C) Chemistry Dept., Moscow State University, 2002
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