ChemNet
 
Previous article Next article Contents  

Ekaterina V. Popova, Victoria E. Tikhomirova, Olga V. Beznos, Natalia B. Chesnokova, Yuri V. Grigoriev, Olga A. Kost

Chitosan nanoparticles the drug delivery system to the anterior segment of the eye

Abstract

Abstract. The effectiveness of drug penetration into the inner tissues of the eye is significantly limited by the barrier effect of the cornea and by the washing out of a drug with tear fluid. To increase the bioavailability of the drug, it was proposed to include the drug in chitosan particles formed by two types of chitosan 5 kDa chitosan and 72 kDa glycol-chitosan. Chitosan particles with incorporated angiotensin-converting enzyme inhibitor enalaprilat, capable to reduce intraocular pressure, were characterized by dynamic light scattering and scanning electron microscopy. Particles formed by 5 kDa chitosan had an average hydrodynamic diameter of 85125 nm and a positive ζ-potential of +213 mV, while particles formed by 72 kDa glycol-chitosan were 440480 nm by size and had ζ-potential of +102 mV. The percentage of inclusion of enalaprilat in chitosan particles was 25% and 40%, respectively. In vivo experiments have shown that the inclusion of the drug in chitosan particles increased the retention time of enalaprilat in the lacrimal fluid of rabbits.
Key words: mucoadhesiveness, chitosan, angiotensin-converting enzyme inhibitor, intraocular pressure, delivery to the eye, lacrimal fluid
Moscow University Chemistry Bulletin.
2023, Vol. 64, No. 2, P. 141
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
   Overview
   Editorial board
   Tables of Contents
   Subscription

The site is supported by Russian Foundation for Basic Research
  The using of published on this page materials is not allowed without special permission
Copyright (C) Chemisty Department of Moscow State University
Web-Editor: B.I.Pokrovskii
Web-design: Copyright (C) MIG and VVM
webmaster@www.chem.msu.su