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A. S. Popov, G. S. Maksimov, A. D. Smolenkov, O. A. Shpigun, A. V. Chernobrovkina

Novel stationary phases for hydrophilic interaction liquid chromatography based on silica covalently modified with polyethylene glycol


Novel stationary phases based on aminopropyl silica covalently modified with polyethylene glycol with different matrix to polymer mass ratio were obtained. Chromatographic properties of the prepared adsorbents were studied using Tanaka test procedure for hydrophilic stationary phases and on the example of separating model mixtures of sugars, amino acids, and water-soluble vitamins. It was shown that polyethylene glycol layer thickness variation not only affects efficiency, but allows one to tailor selectivity toward the polar analytes in hydrophilic interaction liquid chromatography mode.
Key words: HILIC, stationary phase synthesis, polyethylene glycol, sugars, amino acids, water-soluble vitamins.
Moscow University Chemistry Bulletin.
2021, Vol. 62, No. 2, P. 164

Copyright (C) Chemistry Dept., Moscow State University, 2002
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