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K. Yu. Vlasova, S. Ch. Vanzarakshaeva, M. M. Veselov, I. M. Le-Deygen, A. V. Petrunin, A. N. Prusov, A. B. Shuklinov, Y. I. Golovin, A. V. Kabanov, N. L. Klyachko
Magnetic
liposomes for remote controlled high-molecular drugs release under low
frequency non-heating magnetic field
Abstract
Magnetic anionic
liposomes (MALip) conjugated with magnetite magnetic nanoparticles (MNP) were
developed for controlled release of a protease inhibitor (BBI) under exposure
to low frequency non-heating magnetic field (LF AFM). It was shown, that an
increase up to 35% of the protein release rate occurs during the MALip were
exposed to LF AMF (frequency 110 Hz, intensity 75–150 kA/m) during 5–15
minutes. The research provides prospects of the development of remotely
controlled proteins release from liposomes.
Key words:
magnetic liposomes, non-heating low-frequency alternating magnetic field,
controlled drug release.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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