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Ekaterina V. Buravleva, Vladimir L. Voeikov, Sergey E. Kondakov
Study of blood
sedimentation under a dilution of dextran solutions. Blood as active colloid system
Abstract
Abstract. The dynamics of sedimentation of whole blood cells, as well as
erythrocyte mass, has been studied during sequential dilution with dextran
solutions in vitro. Nonmonotonic changes in the optical density of the
boundary between erythrocytes sedimenting both in their own plasma and in model
systems were revealed. The oscillations of both the average rate and the
instantaneous rates of the process recorded at the cell sedimentation boundary
confirm the non-linear and cooperative nature of erythrocyte sedimentation,
which is associated with the formation and separation of phases between the
cellular, liquid and gaseous components of blood. The structural rearrangement
of this dynamic system can be modulated by various factors, for example,
dextran solutions used in clinical practice for blood loss, for detoxification,
treatment and prevention of thrombophlebitis and shock conditions. It was shown
that both the degree of dilution of blood or model systems with dextrans and
their molecular weight change the macro- and microkinetics of the process of
erythrocyte sedimentation. These results are consistent with the phase
hypothesis of sedimentation of blood cells as a biocolloid, and can also be
used in clinical blood transfusion for selecting an individual dosage of
infusion solutions.
Key words: erythrocyte
sedimentation, dextrans, non-linear dynamics, biocolloids,active colloidal
system, in vitro simulation of physiological processes
Copyright (C) Chemistry Dept., Moscow State University, 2002
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