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V. G. Amelin, Modar Mayya, D. S. Bolshakov

Microextraction-colorimetric determination of quaternary ammonium compounds in medicines and disinfectants


A method for the determination of quaternary ammonium compounds in medicines and disinfectants is proposed, based on dispersive liquid-liquid microextraction of QAC associates with eosin and measuring the colorimetric characteristics of the obtained extracts using a smartphone and specialized software. As an analytical signal (Ar), we used the values of colorimetric parameters in the RGB system. Methods for determining the content of chlorides of cetylpyridinium, myristalconium, benzalkonium and benzyldimethyl [3-(myristoylamino)propyl]-ammonium in the drugs Teraflu, Septolete Total, Kalgel, Miramistin, Inokain and Pharmatex have been developed; chlorides of cetylpyridinium, benzalkonium, alkyldimethyl(ethylbenzyl)ammonium, cetyltrimethylammonium, myristyltrimethyl ammonium and didecyldimethylammonium in antiseptic preparations Securol, Akhdez, Stellarium and micellar waters. The limits of detection and determination are in the ranges of 0.0070.100 and 0.020.40 mg/l, respectively. Calibration characteristics are linear with approximation confidence coefficients ≥ 0.98. The relative standard deviation of the analysis results does not exceed 0.130.15. The duration of the analysis was 1520 min.
Key words: digital colorimetry, quaternary ammonium compounds, dispersive liquid-liquid microextraction, smartphone, RGB, medicines and disinfectants.
Moscow University Chemistry Bulletin.
2021, Vol. 62, No. 2, P. 121

Copyright (C) Chemistry Dept., Moscow State University, 2002
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