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V. G. Grigorenko, I. P. Andreeva, G. V. Presnova, D. E. Presnov, E. A. Yakovleva, A. P. Osipov
Silica-based gold
nanoshells: synthesis and application in immunochromatographic assay
Abstract
The method for gold nanoshells synthesis was optimized for
their use as a highly sensitive label in immunochromatographic assay. An
immunochromatographic test system based on gold nanoshells as a visual marker
was developed for early cardiomarker fatty acid binding protein (H-FABP)
detection. The detection limit of the method in the case of gold nanoshells was
more than 2 times lower than that of gold nanoparticles and amounted to 0.5 ng
/ ml for H-FABP.
Key words:
immunochromatographic assay; gold nanoshells; gold nanoparticles; human heart
fatty acid binding protein.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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