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O. I. Vernaya, V. P. Shabatin, A. M. Semenov, T. I. Shabatina, M. Ya. Melnikov
Low temperature
synthesis and antibacterial activity of hybrid systems of gentamicine sulphate
with copper and iron nanoparticles
Abstract
Cryochemical modification methods were used to
obtain hybrid composites of the antibacterial drug gentamicin sulfate and
copper and iron nanoparticles, which are promising precursors of targeted
delivery systems. The resulting systems are antibiotic nanoparticles with a
size of 50–300 nm, including copper and iron nanoparticles with a size of 1–20
nm (according to the results of physicochemical analysis by IR spectroscopy,
X-ray diffraction analysis, dynamic light scattering, scanning and transmission
microscopy). The obtained composites showed higher antibacterial activity
against E. coli, P. aeruginosa, B. cereus compared to the individual components.
Key words:
iron nanoparticles, copper nanoparticles, gentamicin sulfate, antibacterial
activity.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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