Previous article Contents  

A. A. Novitskiy1, A. A. Litvin1, R. V. Shevchenko1, P. O. Bochkov1, O. G. Gribakina1, G. B. Kolyvanov, V. P. Zherdev, K. V. Alekseev, E. V. Blynskaya, D. V. Yudina, V. V. Smirnov

Comparative pharmacokinetics and relative bioavailability of a new anxiolytc GML-1 tablet form


Open, single, crossover, pharmacokinetic study of GML-1 (dose 50 mg|kg) in rabbits after oral administration tablets and substance was performed. Pharmacokinetic parameters were calculated: maximum concentration of GML-1 in the rabbit blood plasma (Cmax), the time of Cmax, the area under “concentration-time” curve, the half-time of GML-1, the relative bioavailability. GML-1 concentrations were detected by HPLC-MS (“ion trap”) by daughter ions. The relative bioavailability of GML-1 in tablets was 101,72±19,96%. in comparison to substance.
Key words: anxiolytics, GML-1, pharmacokinetics, HPLC-MS.
Moscow University Chemistry Bulletin.
2019, Vol. 60, No. 4, P. 270

Copyright (C) Chemistry Dept., Moscow State University, 2002
   Editorial board
   Tables of Contents

The site is supported by Russian Foundation for Basic Research
  The using of published on this page materials is not allowed without special permission
Copyright (C) Chemisty Department of Moscow State University
Web-Editor: B.I.Pokrovskii
Web-design: Copyright (C) MIG and VVM