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A. A. Novitskiy1, A. A. Litvin1, R. V. Shevchenko1, P. O. Bochkov1, O. G. Gribakina1, G. B. Kolyvanov, V. P. Zherdev, K. V. Alekseev, E. V. Blynskaya, D. V. Yudina, V. V. Smirnov
Comparative pharmacokinetics and relative
bioavailability of a new anxiolytc GML-1 tablet form
Abstract
Open, single, crossover, pharmacokinetic
study of GML-1 (dose 50 mg|kg) in rabbits after oral administration tablets and
substance was performed. Pharmacokinetic parameters were calculated: maximum
concentration of GML-1 in the rabbit blood plasma (Cmax), the time
of Cmax, the area under “concentration-time” curve, the half-time of
GML-1, the relative bioavailability. GML-1 concentrations were detected by
HPLC-MS (“ion trap”) by daughter ions. The relative bioavailability of GML-1 in
tablets was 101,72±19,96%. in comparison to substance.
Key words: anxiolytics, GML-1,
pharmacokinetics, HPLC-MS.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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