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E. A. Zaitseva, Yu. I. Golovin, O. A. Kost, I. I. Nikol’skaya, K. Yu. Vlasova, L. Yu. Filatova, A. B. Belova, E. N. Efremenko, I. V. Lyagin, A. D. Aleksashkin, N. V. Nukolova, A. G. Majouga, A. V. Kabanov, N. L. Klyachko
"NANOZYME" technology in Moscow university.
achievements and development perspectives
Abstract
Novel functional bionanosystems developed
in the Lomonosov Moscow State University laboratory “Chemical design of
bionanomaterials” in collaboration with scientists from UNC Eshelman School of
Pharmacy (USA) for therapy and diagnostics based on proteins, enzymes,
polymeric coatings, magnetic nanoparticles are presented in the review. The
properties of enzymes (superoxide dismutase, catalase, organophosphate
hydrolase, lysines of bacteriophages) and other drugs molecules immobilized in
polymeric complexes as well as the methods for targeted drug delivery using
cell-mediated systems and magnetic nanoparticles and operating conditions in
vitro and in vivo are discussed. Physical and chemical
characteristics including function peculiarities data of the nanoformulations
are obtained. The nanoformulations developed demonstrated high potential
therapeutic efficacy for treatment of central nervous system and brain
diseases, inflammations (including inflammatory diseases in the eye), cancer
and infectious diseases, neurotoxic injury and others. The
possibilities of remote control biochemical reactions using a non-heating
low-frequency alternating magnetic field (AMF) for the controlled release of
drugs are analyzed in the review. The experimental results of the AMF effects
on bionanosystems containing magnetic nanoparticles such as changing the
catalytic activities of enzymes bound to magnetic nanoparticles as well as
“disordering” of lipid bilayer in membranes are considered.
Key words: nanomedicine, enzymes, block
copolymers, nanozymes, targeted drug delivery, theranostics, functionalized
magnetic nanoparticles, low-frequency alternating magnetic field, controlled
release of drugs.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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