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A. N. Savchenko V. A. Ol’shevskaya, V. N. Kalinin, A. A. Shtil
Boronated
derivatives of protohemin IX and l-amino acids as potential anticancer agents
Abstract
We synthesized a series of novel water
soluble conjugates of protohemin IX with anionic 1-carba-closo-dodecaborate and
L-amino acids. In these compounds the amino acid residues are bound to the
porphyrin macrocycle via the amide or ester bonds. The antitumor activity of
novel compounds demonstrated their high potency in killing a variety of human
tumor cell lines, including those that expressed molecular determinants of
altered anticancer drug response.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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